Home Antibody All anti-FGD4 antibodies
Also for FGD4 (NM_139241)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 49 and 297 of FGD4|
|WB, IHC, IF
||WB:1:500-1:3000; IHC:1:100; IF:1:100-1:200;
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography. (Protein A or G Sepharose)
|Homo sapiens FYVE, RhoGEF and PH domain containing 4 (FGD4)|
|CMT4H; FRABP; ZFYVE6|
|This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. [provided by RefSeq]|
Signaling by GPCR
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Sample (30 ug of whole cell lysate) A: Molt-4 (anti-FGD4 antibody diluted at 1:1000)
Immunohistochemical analysis of paraffin-embedded SG xenograft, using FGD4(anti-FGD4 antibody) antibody at 1:100 dilution.
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using FGD4(anti-FGD4 antibody) antibody at 1:200 dilution.