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Also for RASSF1 (NM_170714)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 50 and 334 of RASSF1|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography. (Protein A or G Sepharose)
|Homo sapiens Ras association (RalGDS/AF-6) domain family member 1 (RASSF1), transcript variant D|
|123F2; NORE2A; RASSF1A; RDA32; REH3P21|
|This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]|
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Sample(30 ug whole cell lysate) A:293T (anti-RASSF1 antibodydiluted at 1:500)
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using RASSF1(anti-RASSF1 antibody) antibody at 1:100 dilution.