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Anti-UNC13B Antibody

* Buy one primary antibody, get 50% off a GAPDH loading control antibody.

WB(1)

IHC(1)

IF(1)

OriGene Data

Immunogen	Recombinant protein fragment contain a sequence corresponding to a region within amino acids 680 and 927 of human UNC13B
Clone Name		Isotype	IgG
Species Reactivity	Human	Concentration	1mg/ml
Guaranteed Application *	WB, IHC, IF	Suggested Dilutions	WB:1:500-1:3000; IHC:1:500; IF:1:100-1:500;
Buffer	0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification	Purified by antigen-affinity chromatography. (Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens unc-13 homolog B (C. elegans) (UNC13B)
Alternative Name	MUNC13; UNC13; Unc13h2
Database Link	NP_006368
Function	This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq]
Related Pathway

Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • UNC13B - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • UNC13B - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Unc13b - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • UNC13B - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Unc13b - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens unc-13 homolog B (C. elegans) (UNC13B) as transfection-ready DNA • GFP-tagged ORF clone of Homo sapiens unc-13 homolog B (C. elegans) (UNC13B) as transfection-ready DNA Related cDNA Clones • Homo sapiens unc-13 homolog B (C. elegans) (UNC13B) as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)