Anti-TNFSF11 Antibody,

Also for TNFSF11 (NM_033012)

OriGene Data

Immunogen	Synthetic peptide contain a sequence corresponding to a region within amino acids 253 and 317 of RANKL (CD254)
Clone Name		Isotype	IgG
Species Reactivity	Human	Concentration	1mg/ml
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB:1:500-1:3000; IHC:1:100;
Buffer	0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification	Purified by antigen-affinity chromatography. (Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11), transcript variant 2
Alternative Name	CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL; sOdf; TRANCE
Database Link	NP_143026
Function	This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq]
Related Pathway	Cytokine-cytokine receptor interaction

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WB Image

A: Hela ( RANKL (CD254) antibody anti-TNFSF11 antibody diluted at 1:1000)

IHC Image

Immunohistochemical analysis of paraffin-embedded U87 xenograft, using RANKL(anti-TNFSF11 antibody) antibody at 1:100 dilution.

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Anti-TNFSF11 Antibody

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data