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Home Antibody All anti-TBP antibodies

Anti-TBP Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308956
  • Rabbit Polyclonal antibody to TFIID (TATA box binding protein)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401105) , 20ug
100ul 325 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenRecombinant protein fragment contain a sequence corresponding to a region within amino acids 158 and 339 of Human TBP
Clone Name IsotypeIgG
Species ReactivityHuman Concentration7.36mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB:1:500-1:3000; IHC:1:100;
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Affinity purified by Protein A.

Reference Data

Target NameHomo sapiens TATA box binding protein (TBP), transcript variant 1
Alternative NameGTF2D; GTF2D1; HDL4; SCA17; TFIID
Database LinkNP_003185
FunctionInitiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. [provided by RefSeq]
Related Pathway
Wnt Signaling Pathway

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WB Image
Sample (30 ug of whole cell lysate) A: 293T (anti-TBP antibody diluted at 1:500)
IHC Image
Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using TFIID(anti-TBP antibody) antibody at 1:100 dilution.

 

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