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Home Antibody All anti-ROCK1 antibodies

Anti-ROCK1 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA308951 Rabbit polyclonal antibody to ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) 100ul $325 3-7 Days
LC417325 ROCK1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenRecombinant protein fragment contain a sequence corresponding to a region within amino acids 107 and 371 of ROCK1
Clone Name IsotypeIgG
Species ReactivityHuman Concentration0.68mg/ml
Guaranteed Application *WB, IHC, IF, IP Suggested DilutionsICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 158kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.

Reference Data

Target NameHomo sapiens Rho-associated, coiled-coil containing protein kinase 1 (ROCK1)
Alternative NameP160ROCK; ROCK-I
Database LinkNP_005397
Entrez Gene 6093 Human
FunctionThis gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq]
Related PathwayProtein KinaseDruggable Genome Chemokine signaling pathwayVascular smooth muscle contractionWnt signaling pathwayTGF-beta signaling pathwayAxon guidanceFocal adhesionMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
ROCK1 antibody [N1N2], N-term detects ROCK1 protein by western blot analysis. A. 30 ug NIH-3T3 whole cell extract. B. 30 ug C2Cl2 whole cell extract. 5 % SDS-PAGE. ROCK1 antibody [N1N2], N-term (TA308951) dilution: 1:1000

WB Image
ROCK1 antibody [N1N2], N-term detects ROCK1 protein by Western blot analysis. A. 50 ug rat brain lysate/extract. 5 % SDS-PAGE. ROCK1 antibody [N1N2], N-term (TA308951) dilution: 1:500

WB Image
Sample (30 ug of whole cell lysate). A: A431 . B: H1299. C: Molt-4 . 5% SDS PAGE. TA308951 diluted at 1:1000.

IHC Image
Immunohistochemical analysis of paraffin-embedded DLD1 xenograft , using ROCK1(TA308951) antibody at 1:500 dilution.

IF Image
Immunofluorescence analysis of methanol-fixed HeLa, using ROCK1(TA308951) antibody at 1:200 dilution.

IP Image
ROCK1 antibody immunoprecipitates ROCK1 protein in IP experiments. IP Sample: A431 whole cell lysate/extract A : Control with 3 ug of pre-immune rabbit IgG B : Immunoprecipitation of ROCK1 by 3 ug of ROCK1 antibody (TA308951) 5% SDS-PAGE The immunoprecipi


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