Home Antibody All anti-ROCK1 antibodies
Also for ROCK1 (NM_005406)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 107 and 381 of ROCK1|
|WB, IHC, IF
||WB:1:500-1:3000; IHC:1:500; IF:1:100-1:200;
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography. (Protein A or G Sepharose)
|Homo sapiens Rho-associated, coiled-coil containing protein kinase 1 (ROCK1)|
|This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq]|
Signaling by GPCR
TGF Beta Signaling Pathway
Wnt Signaling Pathway
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A: A431 B: H1299 C: Molt-4 (anti-ROCK1 antibody diluted at 1:1000)
Immunohistochemical analysis of paraffin-embedded DLD1 xenograft , using ROCK1(anti-ROCK1 antibody) antibody at 1:500 dilution.
Immunofluorescence analysis of methanol-fixed HeLa, using ROCK1(anti-ROCK1 antibody) antibody at 1:200 dilution.