Home Antibody All anti-PROC antibodies
Also for PROC (NM_000312)
|Recombinant fragment corresponding to a region within amino acids 145 and 461 of Protein C (Uniprot ID#P04070)|
|Human (Predicted: Dog)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Dog (82%)
|Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC)|
|APC; PC; PROC1; THPH3; THPH4|
Entrez Gene 5624 Human
|The PROC gene encodes protein C (EC 188.8.131.52), a vitamin K-dependent plasma glycoprotein that is a key component of the anticoagulant system. Protein C is cleaved to its activated form, 'activated protein C' (APC) on endothelial cells by the thrombin-thrombomodulin complex (MIM 176930; MIM 188040) and then acts as a serine protease to degrade the activated forms of coagulation factors V (F5; MIM 612309) and VIII (F8; see MIM 306700). Protein S (PROS1; MIM 176880), also a vitamin K-dependent plasma protein, functions as a cofactor to activated protein C.[supplied by OMIM]|
|ProteaseDruggable Genome Complement and coagulation cascades|
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Sample (30 ug of whole cell lysate). A: Molt-4 . 10% SDS PAGE. TA308939 diluted at 1:3000