Home All anti-PDE4B antibodies
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Also for PDE4B (NM_001037341)
|489 - 723 of Human PDE4B|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography. (Protein A or G Sepharose)
|Homo sapiens phosphodiesterase 4B, cAMP-specific (PDE4B), transcript variant d|
|DPDE4; PDE4B5; PDEIVB|
|This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]|
Signaling by GPCR
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A: IMR32B: HCT116(anti-PDE4B antibody diluted at 1:1000)