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Home Antibody All anti-PDE4B antibodies

Anti-PDE4B Antibody

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SKU Description Amount Price Availability*  
TA308931 Rabbit polyclonal antibody to Phosphodiesterase 4B (phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)) 100ul $325 3-7 Days
LC421908 PDE4B HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(2)
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Also for PDE4B (NM_001037341)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 489 and 736 of PDE4B (Uniprot ID#Q07343)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Rhesus Monkey) Concentration0.72mg/ml
Guaranteed Application *WB Suggested DilutionsWB:1:500-1:3000
Predicted MW Explanation 83kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Rhesus Monkey (100%)

Reference Data

Target NameHomo sapiens phosphodiesterase 4B, cAMP-specific (PDE4B), transcript variant d
Alternative NameDPDE4; PDE4B5; PDEIVB
Database LinkNP_001032418
Entrez Gene 5142 Human
Entrez Gene 699309 Monkey
FunctionThis gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
Related PathwayDruggable Genome Purine metabolismProgesterone-mediated oocyte maturation

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Sample (30 ug of whole cell lysate) . A: NT2D1. B:  PC-3. 7.5% SDS PAGE . TA308931 diluted at 1:1000.  
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PDE4B antibody detects PDE4B protein by western blot analysis. Whole cell extracts (30 ug) was separated by 7.5% SDS-PAGE, and the membrane was blotted with PDE4B antibody (TA308931) diluted by 1:1000.
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