Home Antibody All anti-KNG1 antibodies
Also for KNG1 (NM_001102416)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 416 of HMW Kininogen|
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, IF
||ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens kininogen 1 (KNG1), transcript variant 1|
|BDK; BK; KNG|
Entrez Gene 3827 Human
|High molecular weight kininogen (HMWK) plays an important role in assembly of the plasma kallikrein (see MIM 147910)-kinin system. The KNG1 gene generates both HMWK and low molecular weight kininogen (LMWK) through alternative splicing. Both HMWK and LMWK contain an identical heavy chain consisting of protein domains 1, 2, and 3. However, HMWK contains a 56-kD light chain that consists of domains 5 and 6H, whereas LMWK contains a unique 4-kD light chain that consists of domain 5L. In both proteins, the heavy and light chains are linked by domain 4, which contains the bradykinin (BK) nonapeptide. BK, which is released by plasma kallikrein, is a potent inflammatory mediator that causes vasodilation and enhanced capillary permeability, induces pain, and stimulates production of nitric oxide and prostacyclin (see MIM 601699) from endothelial cells. During vascular damage, BK stimulates smooth muscle proliferation and intimal hypertrophy. Release of BK from HMWK generates a 2-chain HMWK, termed HMWKa, containing the heavy and light chains joined by a disulfide bond (Merkulov et al., 2008 [PubMed 18000168]).[supplied by OMIM]|
|Secreted ProteinDruggable Genome Complement and coagulation cascades|
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Sample (30 ug of whole cell lysate). A: Molt-4 . 10% SDS PAGE. TA308914 diluted at 1:1000
Immunohistochemical analysis of paraffin-embedded A549 xenograft, using Kininogen 1(TA308914) antibody at 1:500 dilution.
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using Kininogen-1(TA308914) antibody at 1:200 dilution.