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Home Antibody All anti-HLA-DRB4 antibodies

Anti-HLA-DRB4 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308898
  • Rabbit polyclonal antibody to HLA-DRB4 (major histocompatibility complex, class II, DR beta 4)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402894) , 20ug
100ul 325 3-7 Days
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Also for HLA-DRB4 (NM_021983)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRecombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 262 of Human HLA-DRB4
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1mg/ml
Guaranteed Application *WB Suggested DilutionsWB:1:500-1:3000;
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.

Reference Data

Target NameHomo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4)
Alternative NameDR-4; DR4; DRB4; HLA-DR4B
Database LinkNP_068818
FunctionHLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq]
Related Pathway
Hematopoietic cell lineage

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WB Image
Sample(30 ug whole cell lysate) A:Raji (anti-HLA-DRB4 antibody diluted at 1:1000)

 

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