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Home Antibody All anti-HLA-DRB3 antibodies

Anti-HLA-DRB3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308897
  • Rabbit polyclonal antibody to HLA-DRB3 (major histocompatibility complex, class II, DR beta 3)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC411623) , 20ug Explanation
100ul 325 3-7 Days
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IF(1)
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Also for HLA-DRB3 (NM_022555)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 4 and 266 of HLA-DRB3 (Uniprot ID#P79483)
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1mg/ml
Guaranteed Application *IF Suggested DilutionsICC/IF:1:100-1:1000
Predicted MW Explanation 30kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.

Reference Data

Target NameHomo sapiens major histocompatibility complex, class II, DR beta 3 (HLA-DRB3)
Alternative NameHLA-DR3B
Database LinkNP_072049
Entrez Gene 3125 Human
FunctionHLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq]
Related PathwayTransmembrane Cell adhesion molecules (CAMs)Antigen processing and presentationHematopoietic cell lineageType I diabetes mellitusAsthmaAutoimmune thyroid diseaseMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

IF Image
Immunofluorescence analysis of methanol-fixed A549, using HLA-DRB3(TA308897) antibody at 1:500 dilution.

 

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