Home Antibody All anti-GAD1 antibodies
Also for GAD1 (NM_013445)
|Immunogen: Recombinant fragment corresponding to a region within amino acids 5 and 216 of GAD67 (Uniprot ID#Q99259)|
|Human, Mouse, Rat
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens glutamate decarboxylase 1 (brain, 67kDa) (GAD1), transcript variant GAD25|
|CPSQ1; GAD; SCP|
|This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq]|
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A: HepG2 (anti-GAD1 antibody diluted at 1:500)
GAD67 antibody detects GAD1 protein by Western blot analysis of mouse brain lysate/extract (dilution: 1:500).
GAD67 antibody detects GAD1 protein by Western blot analysis of rat brain lysate/extract (dilution: 1:500)
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using GAD67(anti-GAD1 antibody) antibody at 1:200 dilution.