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|Recombinant fragment corresponding to a region within amino acids 217 and 453 of Factor IX (Uniprot ID#P00740)|
|Human (Predicted: Mouse, Dog, Monkey, Pig, Rabbit, Rat, Bovine)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Mouse (80%), Dog (87%), Monkey (96%), Pig (87%), Rabbit (82%), Rat (82%), Bovine (82%)
|Homo sapiens coagulation factor IX (F9), transcript variant 1|
|FIX; HEMB; P19; PTC; THPH8|
Entrez Gene 2158 Human
Entrez Gene 14071 Mouse
Entrez Gene 24946 Rat
Entrez Gene 695578 Monkey
Entrez Gene 404015 Dog
|This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. [provided by RefSeq]|
|Secreted ProteinProteaseDruggable Genome Complement and coagulation cascades|
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Sample (30 ug of whole cell lysate). A: 293T. 10% SDS PAGE. TA308875 diluted at 1:1000.
Immunohistochemical analysis of paraffin-embedded Colon ca, using Factor IX(TA308875) antibody at 1:250 dilution.