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Home Antibody All anti-CASP8 antibodies

Anti-CASP8 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308860
  • Rabbit Polyclonal antibody to Caspase 8 (caspase 8, apoptosis-related cysteine peptidase)
100ul $325 3-7 Days
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WB(1)
IHC(1)
IF(1)
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Also for CASP8 (NM_033356)
cDNA Clone shRNA/siRNA Protein Request Antibody Assay

OriGene Data

ImmunogenRecombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 227 of Human CASP8
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB:1:500-1:3000; IHC:1:100; IF:1:100-1:500;
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.

Reference Data

Target NameHomo sapiens caspase 8, apoptosis-related cysteine peptidase (CASP8), transcript variant C
Alternative NameALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5
Database LinkNP_203520
FunctionThis gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq]
Related Pathway
Apoptosis
MAPK signaling pathway
Toll-like receptor signaling pathway

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WB Image
Sample(30 ug whole cell lysate) A:HeLa S3 (anti-CASP8 antibody diluted at 1:500)
IHC Image
Immunohistochemical analysis of paraffin-embedded gastric ca, using Caspase 8(anti-CASP8 antibody) antibody at 1:100 dilution.
IF Image
Immunofluorescence analysis of methanol-fixed HeLa, using Caspase 8(anti-CASP8 antibody) antibody at 1:200 dilution.

 

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