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Home Antibody All anti-BCL2L1 antibodies

Anti-BCL2L1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308852
  • Rabbit Polyclonal antibody to BCL-x (BCL2-like 1)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC420078) , 20ug Explanation
100ul 325 3-7 Days
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WB(3)
IP(1)
IHC(1)
IF(1)
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Also for BCL2L1 (NM_001191)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 1 and 208 of Bcl-X (Uniprot ID#Q07817)
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse (Predicted: Dog) Concentration0.95mg/ml
Guaranteed Application *WB, IHC, IF, IP Suggested DilutionsICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 26kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Dog (100%)

Reference Data

Target NameHomo sapiens BCL2-like 1 (BCL2L1), transcript variant 2
Alternative NameBcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52
Database LinkNP_001182
Entrez Gene 598 Human
Entrez Gene 12048 Mouse
Entrez Gene 403618 Dog
FunctionThe protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq]
Related PathwayES Cell Differentiation/IPSTransmembraneDruggable Genome ApoptosisJak-STAT signaling pathwayAmyotrophic lateral sclerosis (ALS)Pathways in cancerPancreatic cancerChronic myeloid leukemiaMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample (30 ug of whole cell lysate). . A:NIH-3T3. 12% SDS PAGE. . TA308852 diluted at 1:1000.
WB Image
Sample (30 ug of whole cell lysate). A: HCT116. 12% SDS PAGE. TA308852 diluted at 1:1000.
WB Image
Bcl-X antibody detects BCL2L1 protein by Western blot analysis. A. 30 ug PC-12 whole cell lysate/extract. 12 % SDS-PAGE. Bcl-X antibody (TA308852) dilution: 1:1000
IHC Image
Immunohistochemical analysis of paraffin-embedded SW480 xenograft, using BCL2L1(TA308852) antibody at 1:500 dilution.
IF Image
Immunofluorescence analysis of methanol-fixed A549, using BCL-x(TA308852) antibody at 1:500 dilution.
IP Image
Immunoprecipitation of Bcl-X protein from HCT-116 whole cell extracts using 5 ug of Bcl-X antibody (TA308852). Western blot analysis was performed using Bcl-X antibody (TA308852). An anti-rabbit IgG was used as a secondary reagent.

 

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