Home Antibody All anti-AGT antibodies
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 446 of Human AGT|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography. (Protein A or G Sepharose)
|Homo sapiens angiotensinogen (serpin peptidase inhibitor, clade A, member 8) (AGT)|
|The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq]|
Signaling by GPCR
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Sample(30 ug whole cell lysate) A:HepG2 (anti-AGT antibody diluted at 1:1000)
Immunofluorescence analysis of methanol-fixed HepG2, using Angiotensinogen(anti-AGT antibody) antibody at 1:200 dilution.