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Home Antibody All anti-CD209 antibodies

Anti-CD209 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308815
  • Rabbit polyclonal antibody to DC-SIGN(CD209) (CD209 molecule)
100ul 325 3-7 Days
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OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 210 and 404 of DC-SIGN (Uniprot ID#Q9NNX6)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Human) Concentration1mg/ml
Guaranteed Application * Suggested Dilutions
Predicted MW Explanation 46kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Human (100%)

Reference Data

Target NameHomo sapiens CD209 molecule (CD209), transcript variant 8
Alternative NameCDSIGN; CLEC4L; DC-SIGN; DC-SIGN1
Database LinkNP_001138371
Entrez Gene 30835 Human
FunctionThis gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
Related PathwayDruggable Genome

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