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Home Antibody All anti-DDB1 antibodies

Anti-DDB1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308812
  • Rabbit Polyclonal antibody to DDB1 (damage-specific DNA binding protein 1, 127kDa)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419658) , 20ug Explanation
100ul 325 3-7 Days
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WB(3)
IP(1)
IHC(3)
IF(1)

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 749 and 1140 of DDB1 (Uniprot ID#Q16531)
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse (Predicted: Bovine) Concentration0.81mg/ml
Guaranteed Application *WB, IHC, IF, IP Suggested DilutionsICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:1000-1:10000
Predicted MW Explanation 127kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Bovine (100%)

Reference Data

Target NameHomo sapiens damage-specific DNA binding protein 1, 127kDa (DDB1)
Alternative NameDDBA; UV-DDB1; XAP1; XPCE; XPE; XPE-BF
Database LinkNP_001914
Entrez Gene 1642 Human
Entrez Gene 13194 Mouse
FunctionThis gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. [provided by RefSeq]
Related PathwayDruggable Genome Nucleotide excision repairUbiquitin mediated proteolysis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample (50 ug of whole cell lysate). A: Mouse brain. 5% SDS PAGE. TA308812 diluted at 1:5000.
WB Image
Sample (30 ug of whole cell lysate). A: Hep G2 . 7.5% SDS PAGE. TA308812 diluted at 1:1000.
WB Image
Sample (30 ug of whole cell lysate). . A:NIH-3T3. 7.5% SDS PAGE. . TA308812 diluted at 1:1000.
IHC Image
Immunohistochemical analysis of paraffin-embedded Cal27 Xenograft , using DDB1(TA308812) antibody at 1:500 dilution.
IHC Image
DDB1 antibody detects DDB1 protein at nucleus and cytosol on mouse prostate by immunohistochemical analysis. Sample: Paraffin-embedded mouse prostate. DDB1 antibody (TA308812) dilution: 1:500.
IHC Image
DDB1 antibody detects DDB1 protein at nucleus and cytosol on rat fore brain by immunohistochemical analysis. Sample: Paraffin-embedded rat fore brain. DDB1 antibody (TA308812) dilution: 1:500.
IF Image
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using DDB1(TA308812) antibody at 1:200 dilution.
IP Image
DDB1 antibody immunoprecipitates DDB1 protein in IP experiments. IP Sample: 1000 ug HeLa whole cell lysate/extract A. 40 ug HeLa whole cell lysate/extract B. Control with 2.5 ug of preimmune rabbit IgG C. Immunoprecipitation of DDB1 protein by 2.5 ug of D

 

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