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Home Antibody All anti-MAPK8 antibodies

Anti-MAPK8 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308811
  • Rabbit Polyclonal antibody to JNK1 (mitogen-activated protein kinase 8)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC408400) , 20ug Explanation
100ul 325 3-7 Days
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WB(2)
IF(1)
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Also for MAPK8 (NM_139046)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 5 and 300 of JNK1 (Uniprot ID#P45983)
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse (Predicted: Rat) Concentration0.4mg/ml
Guaranteed Application *WB, IF Suggested DilutionsICC/IF:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 48kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Rat (100%)

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-b1
Alternative NameJNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c
Database LinkNP_620634
Entrez Gene 5599 Human
Entrez Gene 26419 Mouse
Entrez Gene 116554 Rat
FunctionThe protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
Related PathwayProtein KinaseES Cell Differentiation/IPSDruggable Genome MAPK signaling pathwayErbB signaling pathwayWnt signaling pathwayFocal adhesionToll-like receptor signaling pathwayNOD-like receptor signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample (30 ug of whole cell lysate). A: Raji. 10% SDS PAGE. TA308811 diluted at 1:1000.
WB Image
Sample (50 ug of whole cell lysate). A: Mouse brain. 10% SDS PAGE. TA308811 diluted at 1:1000.
IF Image
Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed HeLa, using JNK1(TA308811) antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with anti-alpha tubulin antibody (Red) at 1:2000.

 

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