Home Antibody All anti-DUSP8 antibodies
Also for DUSP8 (NM_004420)
|Synthetic peptide contain a sequence corresponding to a region within amino acids 1 and 14 of Human DUSP8|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens dual specificity phosphatase 8 (DUSP8)|
|C11orf81; HB5; HVH-5; HVH8|
|The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq]|
MAPK signaling pathway
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Sample(30 ug of whole cell lysate) A:Raji (anti-DUSP8 antibody diluted at 1:1000)
Immunofluorescence analysis of paraformaldehyde-fixed A431, using DUSP8(anti-DUSP8 antibody) antibody at 1:200 dilution.