Home Antibody All anti-CASP4 antibodies
Also for CASP4 (NM_033306)
|Synthetic peptide corresponding to a region within amino acids 68 and 162 of Caspase 4 (Uniprot ID#P49662)|
|Human (Predicted: Dog, Rhesus Monkey, Bovine)
|WB, IHC, IF
||ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Dog (92%), Rhesus Monkey (100%), Bovine (93%)
|Homo sapiens caspase 4, apoptosis-related cysteine peptidase (CASP4), transcript variant gamma|
|ICE(rel)II; ICEREL-II; ICH-2; Mih1/TX; TX|
Entrez Gene 837 Human
Entrez Gene 704864 Monkey
Entrez Gene 403724 Dog
|This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq]|
|ProteaseDruggable Genome |
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Sample (30 ug of whole cell lysate). A: Hela. 10% SDS PAGE. caspase-4 antibody. TA308791 diluted at 1:1000.
Immunohistochemical analysis of paraffin-embedded SAS xenograft, using Caspase 4(TA308791) antibody at 1:500 dilution.
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using caspase-4 (TA308791) antibody at 1:200 dilution.