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Home Antibody All anti-CASP4 antibodies

Anti-CASP4 Antibody

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SKU Description Amount Price Availability*  
TA308791 Rabbit Polyclonal antibody to Caspase 4 (caspase 4, apoptosis-related cysteine peptidase) 100ul $325 3-7 Days
LC409623 CASP4 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)
IF(1)

OriGene Data

ImmunogenSynthetic peptide corresponding to a region within amino acids 68 and 162 of Caspase 4 (Uniprot ID#P49662)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Dog, Rhesus Monkey, Bovine) Concentration1mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 43kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Dog (92%), Rhesus Monkey (100%), Bovine (93%)

Reference Data

Target NameHomo sapiens caspase 4, apoptosis-related cysteine peptidase (CASP4), transcript variant gamma
Alternative NameICE(rel)II; ICEREL-II; ICH-2; Mih1/TX; TX
Database LinkNP_150649
Entrez Gene 837 Human
Entrez Gene 704864 Monkey
Entrez Gene 403724 Dog
FunctionThis gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq]
Related PathwayProteaseDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Sample (30 ug of whole cell lysate). A: Hela. 10% SDS PAGE. caspase-4 antibody. TA308791 diluted at 1:1000.
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Immunohistochemical analysis of paraffin-embedded SAS xenograft, using Caspase 4(TA308791) antibody at 1:500 dilution.
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Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using caspase-4 (TA308791) antibody at 1:200 dilution.
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