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Home Antibody All anti-APEX1 antibodies

Anti-APEX1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308774
  • Rabbit polyclonal antibody to APE1 (APEX nuclease (multifunctional DNA repair enzyme) 1)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC429949) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(1)
IF(1)
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Also for APEX1 (NM_080649)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenSynthetic peptide corresponding to a region within amino acids 1 and 45 of APE1 (Uniprot ID#P27695)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Pig, Rhesus Monkey, Chimpanzee) Concentration5.04mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 36kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Affinity purified by Protein A.
Note Seq homology of immunogen across species: Pig (93%), Rhesus Monkey (100%), Chimpanzee (100%)

Reference Data

Target NameHomo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 3
Alternative NameAPE; APE1; APEN; APEX; APX; HAP1; REF1
Database LinkNP_542380
Entrez Gene 328 Human
Entrez Gene 702757 Monkey
FunctionApurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq]
Related PathwayStem cell - PluripotencyTranscription FactorsDruggable Genome Base excision repair

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample (30 ug of whole cell lysate). A: A549. 10% SDS PAGE. TA308774 diluted at 1:3000.
IHC Image
APE1 antibody [N1], N-term detects APEX1 protein at nucleus on Saos2 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded Saos2 xenograft. APE1 antibody [N1], N-term (TA308774) dilution: 1:500.
IF Image
Immunofluorescence analysis of paraformaldehyde-fixed A431, using APE1(TA308774) antibody at 1:200 dilution.

 

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