Home Antibody All anti-APEX1 antibodies
Also for APEX1 (NM_080649)
|Synthetic peptide corresponding to a region within amino acids 1 and 45 of APE1 (Uniprot ID#P27695)|
|Human (Predicted: Pig, Rhesus Monkey, Chimpanzee)
|WB, IHC, IF
||ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Affinity purified by Protein A.
|Seq homology of immunogen across species: Pig (93%), Rhesus Monkey (100%), Chimpanzee (100%)
|Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 3|
|APE; APE1; APEN; APEX; APX; HAP1; REF1|
Entrez Gene 328 Human
Entrez Gene 702757 Monkey
|Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq]|
|Stem cell - PluripotencyTranscription FactorsDruggable Genome Base excision repair|
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Sample (30 ug of whole cell lysate). A: A549. 10% SDS PAGE. TA308774 diluted at 1:3000.
APE1 antibody [N1], N-term detects APEX1 protein at nucleus on Saos2 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded Saos2 xenograft. APE1 antibody [N1], N-term (TA308774) dilution: 1:500.
Immunofluorescence analysis of paraformaldehyde-fixed A431, using APE1(TA308774) antibody at 1:200 dilution.