Home Antibody All anti-E2F1 antibodies
Also for E2F1 (NM_005225)
|Recombinant fragment corresponding to a region within amino acids 133 and 362 of E2F1 (Uniprot ID#Q01094)|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens E2F transcription factor 1 (E2F1)|
|E2F-1; RBAP1; RBBP3; RBP3|
Entrez Gene 1869 Human
|The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq]|
|Transcription FactorsDruggable Genome Cell cyclePathways in cancerPancreatic cancerGliomaProstate cancerMelanomaMore Pathways >> |
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Sample (30 ug of whole cell lysate). A: NIH-3T3. 10% SDS PAGE. TA308764 diluted at 1:500.
Sample (30 ug of whole cell lysate). A: A431 . B: H1299. 10% SDS PAGE. TA308764 diluted at 1:1000.
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using E2F1(TA308764) antibody at 1:200 dilution.