OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-AXIN1 antibodies

Anti-AXIN1 Antibody

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308745
  • Rabbit polyclonal antibody to Axin 1 (axin 1)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418638) , 20ug Explanation
100ul 325 3-7 Days
Add to Shopping Cart
WB(1)

OriGene Data

ImmunogenSynthetic peptide corresponding to a region within amino acids 800 and 862 of AXIN1 (Uniprot ID#O15169)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Mouse, Rat, Zebrafish, Xenopus laevis, Chicken, Bovine) Concentration0.76mg/ml
Guaranteed Application *WB Suggested DilutionsWB:1:500-1:3000
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Mouse (100%), Rat (100%), Zebrafish (100%), Xenopus laevis (85%), Chicken (92%), Bovine (100%)

Reference Data

Target NameHomo sapiens axin 1 (AXIN1), transcript variant 1
Alternative NameAXIN; PPP1R49
Database LinkNP_003493
Entrez Gene 8312 Human
Entrez Gene 12005 Mouse
Entrez Gene 79257 Rat
FunctionThis gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin (cadherin-associated protein), beta 1, 88kDa, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]
Related PathwayStem cell relevant signaling - Wnt Signaling pathwayES Cell Differentiation/IPSDruggable Genome Wnt signaling pathwayPathways in cancerColorectal cancerEndometrial cancerBasal cell carcinoma

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample(30 ug of whole cell lysate). A:A431. B:H1299. 7.5% SDS PAGE. TA308745 diluted at 1:1500

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title