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Home Antibody All anti-PSMB8 antibodies

Anti-PSMB8 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308731
  • Rabbit polyclonal antibody to PSMB8 (proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7))
  • FREE positive control: HEK293T cell transient overexpression lysate (LC418176) , 20ug
100ul $325 3-7 Days
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WB(1)
IHC(1)
IF(1)
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Also for PSMB8 (NM_004159)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRecombinant protein fragment contain a sequence corresponding to a region within amino acids 48 and 244 of PSMB8
Clone Name IsotypeIgG
Species ReactivityHuman Concentration0.38mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB:1:500-1:3000; IHC:1:100; IF:1:100-1:200;
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.

Reference Data

Target NameHomo sapiens proteasome (prosome, macropain) subunit, beta type, 8 (PSMB8), transcript variant 1
Alternative NameALDD; D6S216; D6S216E; JMP; LMP7; NKJO; PSMB5i; RING10
Database LinkNP_004150
FunctionThe proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq]
Related Pathway
Cell cycle

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WB Image
A: Raji (anti-PSMB8 antibody diluted at 1:1000)
IHC Image
Immunohistochemical analysis of paraffin-embedded Cal27 Xenograft, using PSMB8(anti-PSMB8 antibody) antibody at 1:100 dilution.
IF Image
Immunofluorescence analysis of paraformaldehyde-fixed A431, using PSMB8(anti-PSMB8 antibody) antibody at 1:200 dilution.

 

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