Anti-KPNA2 Antibody,

Also for KPNA2 (NM_002266)

OriGene Data

Immunogen	Synthetic peptide contain a sequence corresponding to a region within amino acids 468 and 529 of karyopherin alpha 2
Clone Name		Isotype	IgG
Species Reactivity	Human	Concentration	0.71mg/ml
Guaranteed Application *	WB, IF	Suggested Dilutions	WB:1:500-1:3000; IF:1:100-1:200;
Buffer	0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification	Purified by antigen-affinity chromatography. (Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2)
Alternative Name	IPOA1; QIP2; RCH1; SRP1alpha
Database Link	NP_002257
Function	The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq]
Related Pathway

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WB Image

Sample(30 ug of whole cell lysate) A:HeLa S3 B:HepG2 C:MOLT4 (anti-KPNA2 antibody diluted at 1:500)

IF Image

Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using karyopherin alpha 2(anti-KPNA2 antibody) antibody at 1:200 dilution.

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Anti-KPNA2 Antibody

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data