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Home Antibody All anti-SDHB antibodies

Anti-SDHB Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308686
  • Rabbit Polyclonal antibody to SDHB (succinate dehydrogenase complex, subunit B, iron sulfur (Ip))
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401052) , 20ug Explanation
100ul 325 In Stock
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WB(2)
IF(1)
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Also for SDHB (NM_003000)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenSynthetic peptide corresponding to a region within amino acids 221 and 280 of SDHB (Uniprot ID#P21912)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Rat, Pig, Rhesus Monkey, Bovine) Concentration1mg/ml
Guaranteed Application *WB, IF Suggested DilutionsICC/IF:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 32kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Rat (87%), Pig (100%), Rhesus Monkey (100%), Bovine (89%)

Reference Data

Target NameHomo sapiens succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB)
Alternative NameCWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP
Database LinkNP_002991
Entrez Gene 6390 Human
Entrez Gene 298596 Rat
Entrez Gene 705183 Monkey
FunctionComplex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq]
Related PathwayDruggable Genome Citrate cycle (TCA cycle)Oxidative phosphorylationMetabolic pathwaysAlzheimer's diseaseParkinson's diseaseHuntington's diseaseMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
SDHB antibody [C2C3], C-term detects SDHB protein by Western blot analysis. A. 30 ug THP-1 whole cell lysate/extract. B. 30 ug NCI-H929 whole cell lysate/extract. 12 % SDS-PAGE. SDHB antibody [C2C3], C-term (TA308686) dilution: 1:1000
WB Image
SDHB antibody [C2C3], C-term detects SDHB protein by Western blot analysis. A. 30 ug Neuro2A whole cell lysate/extract. 12 % SDS-PAGE. SDHB antibody [C2C3], C-term (TA308686) dilution: 1:1000
IF Image
Immunofluorescence analysis of methanol-fixed HeLa, using SDHB(TA308686) antibody at 1:200 dilution.

 

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