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Also for DUSP3 (NM_004090)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 150 of Human DUSP3|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens dual specificity phosphatase 3 (DUSP3)|
|The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq]|
MAPK signaling pathway
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Sample (30 ug of whole cell lysate) A: 293T (anti-DUSP3 antibody diluted at 1:1000)
Immunohistochemical analysis of paraffin-embedded N87 xenograft, using DUSP3(anti-DUSP3 antibody) antibody at 1:500 dilution.