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Also for UBE4B (NM_001105562)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 740 and 1020 of UBE4B|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography. (Protein A or G Sepharose)
|Homo sapiens ubiquitination factor E4B (UBE4B), transcript variant 1|
|E4; HDNB1; UBOX3; UFD2; UFD2A|
|The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]|
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Sample (30 ug of whole cell lysate) A: HepG2 (anti-UBE4B antibody diluted at 1:10000)
Immunohistochemical analysis of paraffin-embedded CA922 xenograft, using UBE4B(anti-UBE4B antibody) antibody at 1:500 dilution.