Home Antibody All anti-PRF1 antibodies
Also for PRF1 (NM_001083116)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 9 and 184 of Perforin 1|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens perforin 1 (pore forming protein) (PRF1), transcript variant 2|
|FLH2; HPLH2; P1; PFN1; PFP|
|The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq]|
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A: HepG2 ( Perforin 1 antibody anti-PRF1 antibody diluted at 1:1000)