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Home Antibody All anti-DUSP6 antibodies

Anti-DUSP6 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA308575 Rabbit polyclonal antibody to MKP-3 (dual specificity phosphatase 6) 100ul $325 3-7 Days
LC419629 DUSP6 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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WB(1)
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Also for DUSP6 (NM_001946)
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OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 129 and 381 of MKP-3 (Uniprot ID#Q16828)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Pig, Rhesus Monkey) Concentration0.91mg/ml
Guaranteed Application *WB Suggested DilutionsWB:1:500-1:3000
Predicted MW Explanation 42kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Pig (100%), Rhesus Monkey (100%)

Reference Data

Target NameHomo sapiens dual specificity phosphatase 6 (DUSP6), transcript variant 1
Alternative NameHH19; MKP3; PYST1
Database LinkNP_001937
Entrez Gene 1848 Human
Entrez Gene 708907 Monkey
FunctionThe protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Related PathwayPhosphataseDruggable Genome MAPK signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Sample (30 ug of whole cell lysate). A: A549. 10% SDS PAGE. TA308575 diluted at 1:1000.
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