Home Antibody All anti-DNASE1 antibodies
Also for DNASE1 (NM_005223)
|Recombinant fragment corresponding to a region within amino acids 1 and 282 of DNase I (Uniprot ID#P24855)|
|Human (Predicted: Dog)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Dog (81%)
|Homo sapiens deoxyribonuclease I (DNASE1)|
Entrez Gene 1773 Human
Entrez Gene 403413 Dog
|This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq]|
|Secreted ProteinTransmembraneDruggable Genome |
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Sample (30 ug of whole cell lysate). A: MOLT4 . 10% SDS PAGE. TA308546 diluted at 1:1000
Immunofluorescence analysis of methanol-fixed HeLa, using DNase I(TA308546) antibody at 1:200 dilution.