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Home Antibody All anti-DNASE1 antibodies

Anti-DNASE1 Antibody

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SKU Description Amount Price Availability*  
TA308546 Rabbit Polyclonal antibody to DNase I (deoxyribonuclease I) 100ul $325 In Stock
LC401601 DNASE1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IF(1)

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 1 and 282 of DNase I (Uniprot ID#P24855)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Dog) Concentration1mg/ml
Guaranteed Application *WB, IF Suggested DilutionsICC/IF:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 31kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Dog (81%)

Reference Data

Target NameHomo sapiens deoxyribonuclease I (DNASE1)
Alternative NameDNL1; DRNI
Database LinkNP_005214
Entrez Gene 1773 Human
Entrez Gene 403413 Dog
FunctionThis gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq]
Related PathwaySecreted ProteinTransmembraneDruggable Genome

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Sample (30 ug of whole cell lysate). A: MOLT4 . 10% SDS PAGE. TA308546 diluted at 1:1000
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Immunofluorescence analysis of methanol-fixed HeLa, using DNase I(TA308546) antibody at 1:200 dilution.
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