Home Antibody All anti-F11 antibodies
|Recombinant fragment corresponding to a region within amino acids 1 and 312 of Factor XI (Uniprot ID#P03951)|
|Human (Predicted: Dog, Rabbit)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Dog (83%), Rabbit (82%)
|Homo sapiens coagulation factor XI (F11)|
Entrez Gene 2160 Human
Entrez Gene 475623 Dog
|This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq]|
|Secreted ProteinProteaseDruggable Genome Complement and coagulation cascades|
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Sample(30 ug of whole cell lysate). A:293T. 7.5% SDS PAGE. TA308541 diluted at 1:1000
Immunohistochemical analysis of paraffin-embedded Breast ca, using Factor XI(TA308541) antibody at 1:250 dilution.