Home Antibody All anti-FPGT antibodies
Also for FPGT (NM_003838)
|Recombinant fragment corresponding to a region within amino acids 146 and 453 of FPGT (Uniprot ID#O14772)|
|Human (Predicted: Dog, Monkey, Pig, Rabbit, Bovine)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Dog (83%), Monkey (96%), Pig (84%), Rabbit (82%), Bovine (82%)
|Homo sapiens fucose-1-phosphate guanylyltransferase (FPGT), transcript variant 1|
Entrez Gene 8790 Human
Entrez Gene 100533986 Monkey
Entrez Gene 100533995 Dog
|L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. [provided by RefSeq]|
| Fructose and mannose metabolismAmino sugar and nucleotide sugar metabolismMetabolic pathways|
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Sample(30 ug of whole cell lysate). A:Raji. 7.5% SDS PAGE. TA308488 diluted at 1:500
Immunohistochemical analysis of paraffin-embedded MDA-MB-468 xenograft, using FPGT(TA308488) antibody at 1:100 dilution.