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Anti-PKLR Antibody


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SKU Description Amount Price Availability*  
TA308453 Rabbit Polyclonal antibody to Pyruvate Kinase (liver/RBC) (pyruvate kinase, liver and RBC) 100ul $325 3-7 Days
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OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 1 and 260 of Pyruvate Kinase (liver/RBC) (Uniprot ID#P30613)
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:1000-1:10000
Predicted MW Explanation 62kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.

Reference Data

Target NameHomo sapiens pyruvate kinase, liver and RBC (PKLR), transcript variant 2
Alternative NamePK1; PKL; PKR; PKRL; RPK
Database LinkNP_870986
Entrez Gene 5313 Human
FunctionThe protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Related PathwayDruggable Genome Glycolysis / GluconeogenesisPurine metabolismPyruvate metabolismMetabolic pathwaysInsulin signaling pathwayType II diabetes mellitusMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample (30 ug of whole cell lysate) .   A: 293T.   B: A431.   C: HeLa.   D: HepG2.   E: A375.   7.5% SDS PAGE .   TA308453 diluted at 1:1000.    

WB Image
Pyruvate Kinase (liver/RBC) antibody detects Pyruvate Kinase (liver/RBC) protein by Western blot analysis. A. 20 ug Rat liver lysate/extract. 7.5% SDS-PAGE. Pyruvate Kinase (liver/RBC) antibody (TA308453) dilution: 1:10000.

IHC Image
Immunohistochemical analysis of paraffin-embedded NCIN87 xenograft, using Pyruvate Kinase (liver/RBC)(TA308453) antibody at 1:500 dilution.

IF Image
Pyruvate Kinase (liver/RBC) antibody detects PKLR protein at Cytoplasm by immunofluorescent analysis. Sample: HepG2 cells were fixed in -20â 100% MeOH for 5 min. Green: PKLR protein stained by Pyruvate Kinase (liver/RBC) antibody (TA308453) diluted at 1:


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