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Home Antibody All anti-GALR2 antibodies

Anti-GALR2 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA308347 Rabbit Polyclonal antibody to Galanin Receptor 2 (galanin receptor 2) 100ul $325 2 Weeks
LC401272 GALR2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenSynthetic peptide corresponding to a region within amino acids 212 and 307 of Galanin Receptor 2 (Uniprot ID#O43603)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Mouse, Rat, Bovine) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsIHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 42kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Mouse (94%), Rat (94%), Bovine (94%)

Reference Data

Target NameHomo sapiens galanin receptor 2 (GALR2)
Alternative NameGAL2-R; GALNR2; GALR-2
Database LinkNP_003848
Entrez Gene 8811 Human
Entrez Gene 14428 Mouse
Entrez Gene 29234 Rat
FunctionGalanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq]
Related PathwayTransmembraneDruggable Genome Neuroactive ligand-receptor interaction

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Sample(30 ug whole cell lysate). A:293T. B:H1299. 10% SDS PAGE. TA308347 diluted at 1:1000
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Immunohistochemical analysis of paraffin-embedded Skin, using Galanin Receptor 2(TA308347) antibody(10 ug/ml).
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