Home Antibody All anti-HUS1 antibodies
Also for HUS1 (NM_004507)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 243 of HUS1|
||0.5~1.0 mg/ml (Lot Dependent)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens HUS1 checkpoint homolog (S. pombe) (HUS1), transcript variant 1|
|The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. [provided by RefSeq]|
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A: 293T (anti-HUS1 antibody diluted at 1:1000)
Immunohistochemical analysis of paraffin-embedded CA922 xenograft , using HUS1(anti-HUS1 antibody) antibody at 1:500 dilution.