Home Antibody All anti-PCBP2 antibodies
Also for PCBP2 (NM_005016)
|Synthetic peptide contain a sequence corresponding to a region within amino acids 299 and 362 of PCBP2|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography. (Protein A or G Sepharose)
|Homo sapiens poly(rC) binding protein 2 (PCBP2), transcript variant 1|
|hnRNP-E2; HNRNPE2; HNRPE2|
|The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
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Sample (30 ug of whole cell lysate) A: HepG2 (anti-PCBP2 antibody diluted at 1:500)
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using PCBP2(anti-PCBP2 antibody) antibody at 1:200 dilution.