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Anti-FH Antibody


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SKU Description Amount Price Availability*  
TA307996 Rabbit polyclonal antibody to fumarate hydratase (fumarate hydratase) 100ul $325 3-7 Days
LC400053 FH HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 195 and 473 of fumarate hydratase (Uniprot ID#P07954)
Clone Name IsotypeIgG
Species ReactivityHuman Concentration0.9mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:1000-1:10000
Predicted MW Explanation 55kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.

Reference Data

Target NameHomo sapiens fumarate hydratase (FH)
Alternative NameFMRD; HLRCC; LRCC; MCL; MCUL1
Database LinkNP_000134
Entrez Gene 2271 Human
FunctionThe protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq]
Related PathwayDruggable Genome Citrate cycle (TCA cycle)Metabolic pathwaysPathways in cancerRenal cell carcinoma

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Fumarate hydratase antibody detects FH protein by Western blot analysis. A. 50 ug mouse liver lysate/extract. 7.5% SDS-PAGE. Fumarate hydratase antibody (TA307996) dilution: 1:1000.

WB Image
Fumarate hydratase antibody detects Fumarate hydratase protein by Western blot analysis. A.50 ug rat liver lysate/extract. 10 % SDS-PAGE. Fumarate hydratase antibody (TA307996) dilution: 1:5000

WB Image
Sample (30 ug of whole cell lysate). A: HeLa. B: Hep G2 . 10% SDS PAGE. TA307996 diluted at 1:1000

IHC Image
Immunohistochemical analysis of paraffin-embedded NCIN87 xenograft, using fumarate hydratase (TA307996) antibody at 1:500 dilution.

IF Image
Fumarate hydratase antibody detects Fumarate hydratase protein at mitochondria by immunofluorescent analysis. Sample: HeLa cells were fixed in 2% paraformaldehyde/culture medium at 37â for 30 min. Green: Fumarate hydratase protein stained by Fumarate hyd


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