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Home Antibody All anti-RAG2 antibodies

Anti-RAG2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307957
  • Rabbit polyclonal antibody to RAG2 (recombination activating gene 2)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC424659) , 20ug
100ul $325 3-7 Days
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WB(1)
IHC(1)
IF(1)

OriGene Data

ImmunogenRecombinant protein fragment contain a sequence corresponding to a region within amino acids 271 and 519 of RAG2
Clone Name IsotypeIgG
Species ReactivityHuman Concentration0.37mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB:1:500-1:3000; IHC:1:100; IF:1:100-1:200;
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.

Reference Data

Target NameHomo sapiens recombination activating gene 2 (RAG2), transcript variant 1
Alternative NameRAG-2
Database LinkNP_000527
FunctionThis gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq]
Related Pathway

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WB Image
Sample (30 ug of whole cell lysate) A: Molt-4 (anti-RAG2 antibody diluted at 1:1000)
IHC Image
Immunohistochemical analysis of paraffin-embedded DLD1 Xenograft, using RAG2(anti-RAG2 antibody) antibody at 1:100 dilution.
IF Image
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using RAG2(anti-RAG2 antibody) antibody at 1:200 dilution.

 

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