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Home Antibody All anti-DCTN1 antibodies

Anti-DCTN1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307941
  • Rabbit polyclonal antibody to dynactin 1 (dynactin 1 (p150, glued homolog, Drosophila))
100ul 325 In Stock
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WB(1)
IHC(1)
IF(1)

OriGene Data

ImmunogenSynthetic peptide corresponding to a region within amino acids 1216 and 1278 of DCTN1 (Uniprot ID#Q14203)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Mouse, Rat, Bovine) Concentration1 mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 142kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Mouse (100%), Rat (92%), Bovine (92%)

Reference Data

Target NameHomo sapiens dynactin 1 (DCTN1), transcript variant 4
Alternative NameDAP-150; DP-150; P135
Database LinkNP_001128513
Entrez Gene 1639 Human
Entrez Gene 13191 Mouse
Entrez Gene 29167 Rat
FunctionThis gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq]
Related PathwayDruggable Genome Huntington's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample (30 ug of whole cell lysate). A: JurKat. 5% SDS PAGE. TA307941 diluted at 1:3000.
IHC Image
Immunohistochemical analysis of paraffin-embedded OVCA, using dynactin 1(TA307941) antibody at 1:100 dilution.
IF Image
Confocal immunofluorescence analysis (Olympus FV10i) of methanol-fixed HeLa, using DCTN1(TA307941) antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with anti-alpha tubulin antibody (Red) at 1:2000.

 

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