Home Antibody All anti-DCTN1 antibodies
Also for DCTN1 (NM_001135041)
|Synthetic peptide contain a sequence corresponding to a region within amino acids 1216 and 1278 of dynactin 1|
|WB, IHC, IF
||WB:1:500-1:3000; IHC:1:100; IF:1:100-1:200;
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens dynactin 1 (DCTN1), transcript variant 4|
|DAP-150; DP-150; P135|
Entrez Gene 1639 Human
|This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq]|
|Druggable Genome Huntington's disease|
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A: JurKat (anti-DCTN1 antibody diluted at 1:3000
Immunohistochemical analysis of paraffin-embedded OVCA, using dynactin 1(anti-DCTN1 antibody) antibody at 1:100 dilution.
Immunofluorescence analysis of methanol-fixed HeLa, using dynactin 1(anti-DCTN1 antibody) antibody at 1:200 dilution.