OriGene Technologies, Inc.
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-LAMB1 antibodies

Anti-LAMB1 Antibody EPR3190(2)

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307880
  • Rabbit monoclonal antibody against Laminin Beta 1(clone EPR3190(2))
100ul 325 In Stock
Add to Shopping Cart
WB(1)
FC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Laminin Beta 1 was used as an immunogen.
Clone NameEPR3190(2) IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, FC Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:100 - 1:500
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens laminin, beta 1 (LAMB1)
Alternative NameCLM; LIS5
Database LinkNP_002282
FunctionLaminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms, which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. Some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. The beta chain isoform, laminin beta 1, has 7 structurally distinct domains that it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. It is involved in cell attachment and chemotaxis; binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.
Related Pathway
Focal Adhesion

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Laminin beta 1 antibody [EPR3190(2)]; All lanes : Anti-Laminin beta 1 antibody [EPR3190(2)] at 1/1000 dilution.Lane 1 : Human fetal kidney lysate.Lane 2 : A431 lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 198 kDa.
FC Image
Flow Cytometry - Laminin beta 1 antibody [EPR3190(2)]; Flow cytometric analysis of permeabilized A431 cells using TA307880 (red) at a diluiton of 1/100 or a rabbit IgG (negative) (green).

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title