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Anti-LAMB1 Antibody EPR3190(2)


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SKU Description Amount Price Availability*  
TA307880 Rabbit monoclonal antibody against Laminin Beta 1(clone EPR3190(2)) 100ul $325 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Laminin Beta 1 was used as an immunogen.
Clone NameEPR3190(2) IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, FC Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:100 - 1:500
Predicted MW Explanation 198 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for ICC,IHC-P or IP.

Reference Data

Target Namelaminin subunit beta 1
Alternative NameCLM|LIS5
Database LinkNP_002282
Entrez Gene 3912 Human
Entrez Gene 16777 Mouse
Entrez Gene 298941 Rat
FunctionLaminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms, which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. Some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. The beta chain isoform, laminin beta 1, has 7 structurally distinct domains that it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. It is involved in cell attachment and chemotaxis; binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.
Related PathwaySecreted ProteinDruggable Genome Focal adhesionECM-receptor interactionPathways in cancerSmall cell lung cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Laminin beta 1 antibody [EPR3190(2)]; All lanes : Anti-Laminin beta 1 antibody [EPR3190(2)] at 1/1000 dilution.Lane 1 : Human fetal kidney lysate.Lane 2 : A431 lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 198 kDa.

FC Image
Flow Cytometry - Laminin beta 1 antibody [EPR3190(2)]; Flow cytometric analysis of permeabilized A431 cells using TA307880 (red) at a diluiton of 1/100 or a rabbit IgG (negative) (green).


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