Ferritin is important in iron homeostasis. It is the main iron-storage protein, composed of two partially homologous subunits, heavy and light chains. Ferritin molecules in cells containing high levels of iron tend to be rich in light chains and may have a long-term storage function, whereas heavy-rich ferritins are more active in iron metabolism (1, 2). Mutations in ferritin cause hereditary hyperferritinemia-cataract syndrome and neuroferritinopathy, associated with inflammation. Elevated levels of ferritin are reported as characteristics of adult-onset Still's disease and hemophagocytic syndrome, also associated with inflammation (3).
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