Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors (1). Interleukin-8 (IL-8) belongs to a family of small, structurally related cytokines similar to platelet factor 4. It is produced by phagocytes and mesenchymal cells exposed to inflammatory stimuli (e.g., interleukin-1 or tumor necrosis factor) and activates neutrophils inducing chemotaxis, exocytosis and the respiratory burst. In vivo, IL-8 elicits a massive neutrophil accumulation at the site of injection (2). It has recently been shown that IL-8, through its effects on the macrophage and endothelial cell, may be involved in the pathogenesis of atherosclerosis (3).
Cytokine-cytokine receptor interaction
Senescence and Autophagy
Signaling by GPCR
Toll-like receptor signaling pathway
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