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Anti-IRS1 PHOSPHO Antibody EPR259(2)
Also for IRS1 (NM_005544)
|A phospho specific peptide corresponding to residues surrounding Tyrosine 632 of human IRS-1 was used as an immunogen. This antibody only detects IRS-1 phosphorylated at Tyrosine 632.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens insulin receptor substrate 1 (IRS1)|
Entrez Gene 3667 Human
|Insulin receptor substrates (IRS), the major intracellular substrates of the insulin receptor (IR), are adaptor proteins that transduce signals from the IR to downstream effectors that are important for the biological effect of insulin (1, 2). After insulin stimulation, IRS proteins are rapidly phosphorylated on multiple tyrosine residues. Once phosphorylated, IRS proteins bind and activate Grb-2, SHP2 and the PI3-K p85 subunit (2, 3). IRS-1 functions as one of the key regulators of IR and the insulin-like growth factor-1 receptor. Disruption of IRS-1 causes growth retardation and insulin resistance associated with hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation (4, 5).|
|Druggable Genome Neurotrophin signaling pathwayInsulin signaling pathwayAdipocytokine signaling pathwayType II diabetes mellitus|
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Western blot - IRS1 (phospho Y632) antibody [EPR259(2)]; All lanes : Anti-IRS1 (phospho Y632) antibody [EPR259(2)] at 1/1000 dilution.Lane 1 : 293T cell lysate, untreated.Lane 2 : 293T cell lysate treated with Alkaline Phosphatase.Lysates/proteins at 10 ug per lane.Secondary.HRP-labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 132 kDa.