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Home Antibody All anti-FGFR2 antibodies

Anti-FGFR2 Antibody EPR5180


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307869 Rabbit monoclonal antibody against FGF Receptor 2(clone EPR5180) 100ul $325 In Stock
LC400050 FGFR2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for FGFR2 (NM_000141)
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the extracellular domain of human FGF Receptor 2 was used as an immunogen.
Clone NameEPR5180 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100
Predicted MW Explanation 92 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IHC-P.

Reference Data

Target NameHomo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 1
Alternative NameBBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25
Database LinkNP_000132
Entrez Gene 2263 Human
Entrez Gene 14183 Mouse
Entrez Gene 25022 Rat
FunctionFGF Receptor 2 is a member of the fibroblast growth factor receptor family, whose amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGF Receptor 2 is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis.
Related PathwayProtein KinaseSecreted ProteinTransmembraneDruggable Genome MAPK signaling pathwayEndocytosisRegulation of actin cytoskeletonPathways in cancerProstate cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - FGFR2 antibody [EPR5180]; All lanes : Anti-FGFR2 antibody [EPR5180] at 1/1000 dilution.Lane 1 : MCF7 cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : K562 cell lysate.Lane 5 : T47-D cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 92 kDa.Observed band size : 145 kDa .


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