Homo sapiens ubiquitin-conjugating enzyme E2N (UBE2N)
Synonyms:
UBC13; UbcH-ben; UbcH13
Immunogen
A synthetic peptide corresponding to residues in human UBC-13 was used as an immunogen.
Buffer
Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
UBC-13 is a ubiquitin-conjugating enzyme which plays a role in the control of progress through the cell cycle and differentiation. It also plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. UBC-13 acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair (1). In addition, UBC-13 is responsible for noncanonical ubiquitination of TNF receptor-associated factor (TRAF)-family adapter proteins involved in Toll-like receptor and TNF-family cytokine receptor signaling, which are regulators of innate immunity (2).
Related Pathway
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