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Home Antibody All anti-FANCD2 antibodies

Anti-FANCD2 PHOSPHO Antibody EPR2278(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307855
  • Rabbit monoclonal antibody against FANCD2 Phospho (pS1404)(clone EPR2278(2)) (Phospho-Specific)
100ul 325 In Stock
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WB(1)
IF(1)

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Serine 1404 of human FANCD2 was used as an immunogen. This antibody only detects FANCD2 phosphorylated at Serine 1404.
Clone NameEPR2278(2) IsotypeTissue culture supernatant
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsICC/IF: 1:200; WB: 1:1000 - 1:10000
BufferDoes not react with Rat. Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens Fanconi anemia, complementation group D2 (FANCD2), transcript variant 1
Alternative NameFA-D2; FA4; FACD; FAD; FAD2; FANCD
Database LinkNP_149075
Entrez Gene 2177 Human
Entrez Gene 211651 Mouse
FunctionThe Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group, FANCH, is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. FANCD2 is also known as Fanconi anemia group D2 protein. It is monoubiquitinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair.
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - FANCD2 (phospho S1404) antibody [EPR2278(2)]; All lanes : Anti-FANCD2 (phospho S1404) antibody [EPR2278(2)] at 1/1000 dilution.Lane 1 : HeLa cell lysate, untreated.Lane 2 : HeLa cell lysate treated with Alkaline Phosphatase.Lysates/proteins at 10 ug per lane.Secondary.HRP-labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 166 kDa.
IF Image
Immunocytochemistry/ Immunofluorescence - Anti-FANCD2 (phospho S1404) antibody [EPR2278(2)]; TA307855 (1/200) staining FANCD2 (phospho S1404) in HeLa cells (green). Cells were treated with Bleomycin for 2hrs to induce DNA damage, fixed in paraformaldehyde, permeabilized with 0.5% Triton X-100 and counterstained with DAPI in order to highlight the nucleus (red).

 

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