Home All anti-UPF1 antibodies
Anti-UPF1 Antibody EPR4681
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for UPF1 (NM_002911)
|A synthetic peptide corresponding to residues in human RENT1 / hUPF1 was used as an immunogen.|
||FC: 1:10 - 100, ICC: 1:100 - 250, IHC: 1:100 - 250, IP: 1:10 - 100, WB: 1:10,000-50,000,
|Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens UPF1 regulator of nonsense transcripts homolog (yeast) (UPF1)|
|HUPF1; NORF1; pNORF1; RENT1; smg-2|
|RENT1 / hUPF1 is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. RENT1 / hUPF1 is located only in the cytoplasm. It interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for RENT1 / hUPF1.|
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Western blot analysis on (A) HuT-78, (B) Raji, (C) SH-SY5Y, and (D) HeLa cell lysates using anti-RENT1 / hUPF1 RabMAb .
Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-RENT1 / hUPF1 RabMAb .