Home All anti-ATG12 antibodies
Anti-ATG12 Antibody EPR4799
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for ATG12 (NM_004707)
|A synthetic peptide corresponding to residues in human Atg12 was used as an immunogen.|
||FC: 1:10-100, ICC: 1:100-250, IHC: 1:50-100, IP: 1:10-100, WB: 1:1,000-10,000,
|Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens autophagy related 12 (ATG12), transcript variant 1|
|APG12; APG12L; FBR93; HAPG12|
|Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. Atg12 is the human homolog of a yeast protein involved in autophagy (1). It is essential for Atg12 conjugation, and the ATG12-ATG5 conjugate is necessary to form autophagic vesicles (2). The E3-like activity of the Atg12-Atg5 conjugate potentiates the formation of Atg8-PE; making the autophagic pathway analogous to ubiquitin-like pathways where an E3 conjugation ligase is required (3).|
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Western blot analysis on (A) THP-1, (B) HepG2, (C) Raji, and (D) fetal kidney lysates using anti-Atg12 RabMAb .
Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-Atg12 RabMAb .